Multipoint Recognition of Molecular Conformations with Organocatalysts for Asymmetric Synthetic Reactions

Organocatalysts activate substrates through mild noncovalent and covalent interactions, their cooperative actions at multiple catalytic sites are essential even in intrinsically rapid organic reactions such as intramolecular cyclizations. The enzyme-like system is effective for recognizing specific molecular conformations of substrates, which continually change under reaction conditions, multipoint thereby leading to high stereoselectivity. On the basis this concept, we developed a range organocatalytic asymmetric synthetic reactions, challenging using other categories catalysts. proposed catalysis was applied various manners induction including those accompanied by not only facial selectivity but also kinetic resolution (KR), dynamic (DKR), desymmetrization, transformation (DYKAT). They enabled transformations hetero-Michael addition, construction axial chirality, ?,?-unsaturated acylammonium catalysis, advanced methods heterocycle synthesis, tetrasubstituted chiral carbons, enantioselective synthesis axially compounds, library pharmaceutically potential compounds. This study expanded chemistry bifunctional organocatalysis. review provides comprehensive account our achievements regarding recognition with organocatalysts reactions. Organocatalysis activations,